If you’re looking for a great apple pie, here it is. Great texture and flavor, plus a 28% calorie reduction from a traditional recipe.

Pastry for double-crust 9-inch pie
3 tablespoons cornstarch
1 cup Equal® Spoonful*
3/4 teaspoon ground cinnamon
1/4 teaspoon ground nutmeg
1/4 teaspoon salt
8 cups peeled, cored, sliced Granny Smith or other baking apples (about 8 medium)

1. Roll 1/2 the pastry on floured surface into circle 1-inch larger than inverted 9-inch pie plate. Ease pastry into plate.
2. Combine cornstarch, Equal®, cinnamon, nutmeg and salt. Sprinkle over apples in large bowl and toss to coat. Arrange apples in pie crust.
3. Roll remaining pastry into circle large enough to fit top of pie. Place over apples. Seal edges, trim and flute. Cut a few slits in top of pastry to allow steam to escape. Bake in preheated 400°F oven 40 to 50 minutes or until crust is golden and apples are tender.
4. Cool on wire rack. Serve warm or at room temperature.

Makes 8 servings.

* May substitute 24 packets Equal sweetener

Nutrition Information Per Serving (1/8 of pie): calories 253, protein 2 g, carbohydrate 42 g, fat 10 g, cholesterol 10 mg, sodium 224 mg.

Food Exchanges: 1 fruit, 1 1/2 starch, 2 fat.

Guidelines For Type 2 Diabetes - Benefits From Newer Agents For Blood Glucose Control

Merck Sharp & Dohme Limited (MSD) welcomes the publication of the guideline for type 2 diabetes newer agents from the National Institute for Health and Clinical Excellence (NICE) in the UK, which recommends considering a range of newer therapy options, including ‘Januvia’ (sitagliptin). The guideline recommends that the DPP-4 inhibitor class, which includes sitagliptin, should be considered as a second line therapy instead of a sulphonylurea (SU) when blood glucose control remains or becomes inadequate (HbA1c ≥ 6.5% or other higher level agreed with the individual) with metformin in patients at significant risk of hypoglycaemia or its consequences, or if a patient does not tolerate an SU or an SU is contraindicated.

Professor Anthony Barnett, a leading diabetologist from the UK said, “One of the key issues when considering treatment options is striking a balance between achieving optimal glycaemic control while also minimising the risk of hypoglycaemia, and the newer treatments provide us with a wider choice of options. NICE should be applauded for recognising these newer agents, as this represents a significant milestone in the treatment of type 2 diabetes and may have an impact across the rest of Europe. We now have an array of effective treatment options to offer appropriate patients whose blood glucose is not adequately controlled by first-line treatments plus diet and exercise, to help get their blood sugar under control in order to carry on with their everyday lives.”

It is estimated that there are over 53.2 million people in Europe living with diabetes and that this figure is set to rise to 64.1 million by 2025.2 A recent MSD Diabetes survey of healthcare professionals (HCPs) across Europe found that the majority (78%) felt that fewer prescribing restrictions would aid more effective disease management.3

Some of the newer agents, such as the DPP-4 class, have a lower risk of hypoglycaemia and weight gain. As highlighted within the NICE guideline, the latest data on the DPP-4 inhibitor sitagliptin has shown that treatment with sitagliptin was associated with fewer hypoglycaemic events compared to treatment with metformin and glipizide, a sulphonylurea, 5% versus 32% respectively.4 When added to a sulfonylurea, sitagliptin has been associated with an increased risk of hypoglycaemia. Therefore, a reduction in the dose of the sulphonylurea may be necessary.

Dr Martin Hadley-Brown, chairman of the Primary Care Diabetes Society in the UK, said, “The guideline for type 2 diabetes newer agents is important for healthcare professionals because it helps clarify which patients are appropriate candidates for these newer treatments. With a chronic condition such as diabetes it is essential that patients are educated about their condition, have access to a wide range of treatment options and maintain the best quality of life possible. The guideline for type 2 diabetes newer agents certainly supports these efforts.”

In addition, the NICE guideline recognises the role of sitagliptin as the only DPP-4 inhibitor licensed for use in triple therapy with metformin and an SU where metformin and an SU do not adequately control blood sugar (HbA1c ≥7.5% or other higher level agreed with the individual) and insulin is considered inappropriate or unacceptable to the patient.1

As a once-daily tablet, sitagliptin provides a convenient treatment option for patients and has over ten million prescriptions worldwide since launch.5 “We are delighted that, in its guideline for type 2 diabetes newer agents, NICE has recognised the DPP-4 inhibitor class as a potential alternative to SU in selected patients” Dr Paul Leigh, MSD Diabetes, commented. “At MSD, we strive to develop new medicines that can make a difference to patients’ lives, so it is pleasing to know that patients and HCPs can now benefit from a wider range of treatments.”

About sitagliptin

Sitagliptin is a member of a class of oral anti-hyperglycaemic agents called dipeptidyl peptidase 4 (DPP-4) inhibitors and is licensed in the UK for the treatment of type 2 diabetes in combination with either metformin and/or a sulphonylurea, or in certain patients, with a PPARу agonist (i.e. thiazolidinedione), when diet and exercise plus the other agent(s) do not provide adequate glycaemic control.6

Sitagliptin enhances the body’s own ability to lower blood sugar levels by increasing the levels of the body’s own active incretins, called GLP-1 and GIP.

The recommended dose of sitagliptin is 100mg once daily, with or without food, for all approved indications.6

Sitagliptin should not be used in patients with moderate or severe renal impairment or in patients with hepatic insufficiency. It is contraindicated in patients with: hypersensitivity to the active substances or to any of the excipients; diabetic ketoacidosis, diabetic pre-coma; acute conditions with the potential to alter renal function; acute or chronic disease which may cause tissue hypoxia; acute alcohol intoxication, alcoholism; or in woman who are lactating or pregnant. No liver function tests need to be performed prior to the initiation of treatment. See Summary of Product Characteristics for further details.

About hypoglycaemia

Hypoglycaemia occurs when the level of glucose in the blood falls too low, usually under 4 mmol/l. People with diabetes who take insulin and/or certain diabetes tablets are at risk of having hypoglycaemia. It may occur if someone has taken too much diabetes medication, delayed or missed a meal or snack, not eaten enough carbohydrate, taken part in unplanned or more strenuous exercise than usual, and has been drinking alcohol without food. Sometimes there is no obvious cause. When hypoglycaemia happens the person often experiences ‘warning signs’, which occur as the body tries to raise the blood glucose level. These ‘warning signs’ vary from person to person but often include feeling shaky, sweating, tingling in the lips, going pale, heart pounding, confusion and irritability.

Treatment is usually very simple and requires taking some fast acting carbohydrate, such as a sugary drink or some glucose tablets, and following this up with some longer acting carbohydrate, such as a cereal bar. If left untreated the person might, eventually, become unconscious and would need to be treated with an injection of glucagon (a hormone that raises blood glucose levels). But in the vast majority of cases the body will release its own stores of glucose and raise the blood glucose level to normal, though this may take several hours.7